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Glycosaminoglycan synthesis: Increases genes encoding enzymes synthesizing GAGs (hyaluronic acid, chondroitin sulfate, heparan sulfate)

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13 C NMR (100 MHz, CDCl 3 ): (ppm): 159.83, 151.91, 144.77, 143.46, 143.43, 143.25, 139.96, 133.16, 131.98, 131.89, 130.99, 129.54, 128.76, 128.45, 128.09, 127.80, 127.77, 114.73, 113.52, 81.98

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10.7759/cureus.48276 141

Bioavailability: NAC has an oral bioavailability of approximately 6-10% due to extensive first-pass metabolism, but the deacetylated cysteine that reaches tissues effectively drives glutathione synthesis [9]